When acidity in the blood increases, an individual's respiratory rate increases to help maintain the pH balance. This is a compensatory mechanism that is activated when there is an increase in acid production or decrease in acid removal from the body.
Excessive carbon dioxide (CO2) or reduced oxygen (O2) in the blood stimulates the respiratory center of the brain, which increases the respiratory rate. This leads to hyperventilation and helps eliminate excess CO2 from the body through the lungs. The elimination of CO2 through exhalation causes the pH of the blood to return to normal levels by reducing its acidity level.
A decrease in the respiratory rate, on the other hand, leads to acidosis, which occurs when the pH of the blood drops below 7.35. This condition is life-threatening and can cause severe health problems. Therefore, it is essential to maintain the acid-base balance in the body through proper respiration, which helps regulate the pH levels.
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Tonia Gonzales loves singing high notes during her performances. Each of her performances lasts 3 hours and she can sweat at
around 2 liters per hour (sweat is less concentrated than the extracellular fluid in the body). What effect would this loss have on
urine concentration and rate of production? Explain the mechanisms involved.
The loss of sweat during Tonia Gonzales' performances would increase urine production and decrease urine concentration.
When Tonia sings high notes during her performances, she experiences increased physical exertion, which leads to sweating. Sweating is the body's way of regulating its temperature and maintaining homeostasis. During a 3-hour performance, with an average sweat rate of 2 liters per hour, Tonia would lose approximately 6 liters of sweat.
The loss of fluid through sweating triggers the body's compensatory mechanisms to maintain fluid balance. One of these mechanisms involves the kidneys. The kidneys play a crucial role in regulating the concentration and volume of urine. When the body loses water through sweating, the kidneys respond by conserving water to prevent dehydration. As a result, the urine becomes more concentrated. In other words, the kidneys reabsorb more water from the filtrate, reducing its volume and increasing its concentration.
However, in Tonia's case, the sweat she loses is less concentrated than the extracellular fluid in her body. This means that the loss of sweat would dilute the extracellular fluid, including the blood plasma. To restore the balance, the kidneys would excrete more water and produce a larger volume of urine. The increased urine production helps eliminate the excess water and maintain the body's fluid balance.
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1. The blood-brain barrier is a layer of myelin that separates the brain from the carotid arteries, preventing too much blood from entering the brain at one time.
True or False?
2. Which of the following experiments with rodents would require stereotaxic surgery to be performed?
a. Testing the effects of an anti-anxiety drug on elevated plus maze behavior in rats
b. Testing the effects of housing environment on aggressive behavior in the colony-intruder test in rats
c. Testing the effects of lesioning the amygdala on fear conditioning performance in mice
d. Testing the effects of overexpressing a gene on memory abilities in mice
3. At six weeks gestation, genetically-male human fetuses have only a Wolffian system, and genetically-female human fetuses have only a Müllerian system.
True or False
4. Which of the following is an example of DEMASCULINIZATION
a. Orchidectomy
b. Development of ovaries
c. production of SRY protein
d. Hysterectomy
The blood-brain barrier is not a layer of myelin that separates the brain from the carotid arteries. False.
Stereotaxic surgery would be required for the following experiment:
c. Testing the effects of lesioning the amygdala on fear conditioning performance in mice.
Stereotaxic surgery is a technique used to precisely target specific areas of the brain in animal experiments. It involves the use of a specialized apparatus that allows researchers to position electrodes or cannulae in precise locations within the brain. This technique is commonly used in neuroscience research to manipulate and study specific brain regions.
In the given experiment, the researchers aim to investigate the effects of lesioning (damaging) the amygdala, which is a part of the brain involved in fear and emotional processing, on fear conditioning performance in mice. To perform this experiment, the researchers would need to use stereotaxic surgery to accurately target and lesion the amygdala in the mice.
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The warning sign of skin cancer in which a mole or lesion has an irregular shape is known as?
O symmetry O asymmetry O irregularity
O scaliness
The warning sign of skin cancer in which a mole or lesion has an irregular shape is known as asymmetry. One of the most common warning signs of skin cancer is an asymmetrical mole. Moles are typically circular or oval, with an even shape and smooth edges.
An irregular mole or lesion is one of the most frequent early symptoms of skin cancer. The mole's shape, color, and size are all factors to consider. If a mole has jagged or uneven edges, it is asymmetrical. A mole's size should be smaller than 6 mm or approximately the size of a pencil eraser. Moles should also be uniform in color. Moles that are scaly, crusty, or bleeding should be reported.
Asymmetry is a warning sign of skin cancer in which a mole or lesion has an irregular shape. It is crucial to keep an eye on your moles and have them evaluated by a dermatologist regularly. Skin cancer is frequently treated effectively if detected early. Protect your skin from the sun's harmful rays by wearing protective clothing, using sunscreen, and avoiding tanning beds.
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During the process of diffusion, solute particles will generally move from an area of high solute concentration, to an area of low solute concentration. This happens because... solute particles are drawn to regions of high solvent concentration solute particles move away from regions of high solute concentration the random motion of particles suspended in a fluid results in their uniform distribution. solute particles tend to move until they are uniformly distributed within the solvent, and stop moving.
Diffusion is a passive process that does not require energy. This is why the movement of molecules occurs from an area of high concentration to an area of low concentration. In the case of solute particles, they move until they are uniformly distributed within the solvent.
During the process of diffusion, solute particles will generally move from an area of high solute concentration, to an area of low solute concentration. This happens because the random motion of particles suspended in a fluid results in their uniform distribution .
Diffusion happens due to the kinetic energy that causes a random motion of molecules. When a molecule collides with another molecule or the wall of the container it is in, the kinetic energy of the molecule is transferred to the molecules it collides with, causing them to move in different directions.
Diffusion can occur in a variety of mediums, including gases, liquids, and solids. It plays a significant role in various biological processes. For example, it helps transport nutrients and oxygen to cells and allows for the excretion of waste products. Diffusion is a passive process that does not require energy.
This is why the movement of molecules occurs from an area of high concentration to an area of low concentration. In the case of solute particles, they move until they are uniformly distributed within the solvent.
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During the process of diffusion: "The random motion of particles suspended in a fluid results in their uniform distribution."
What is diffusion?During the process of diffusion, solute atoms move from an area of extreme solute aggregation to an extent of low solute aggregation. This motion happens due to the chance motion of atoms postponed in a fluid.
As solute particles are changeable motion, they bang into each one and with the firm atoms, generating them to open and enhance evenly distributed. This process persists as far as the solute pieces are evenly delivered inside the stable.
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What possible "explanatory story" might explain the observation described above?
How would you test your hypothesis made above?
Answer the two questions in 5- 10 sentences.
The possible explanatory story for Alex's growth spurt could be that he experienced a delayed onset of puberty compared to his peers. During his childhood, his body may have been slower in initiating the hormonal changes associated with puberty, resulting in a delayed growth pattern. However, as he entered his teenage years, his body caught up and began producing the necessary hormones at a higher rate, leading to a sudden increase in height and surpassing his friends.
Testing the hypothesis:
To test the hypothesis that Alex's growth spurt was a result of a delayed onset of puberty, several steps can be taken. Firstly, collecting data on Alex's growth patterns and comparing them with standardized growth charts can provide insights into his growth trajectory.
This would involve tracking his height and age over time to identify any deviations or delays in growth.
Additionally, hormonal analysis can be conducted to measure the levels of growth hormones and sex hormones in Alex's body during different stages of his development. Comparing these hormone levels with established norms for puberty can provide evidence of a delayed onset.
Furthermore, comparing Alex's growth patterns with those of his family members can also provide valuable information. If there is a history of delayed puberty or growth spurts in his family, it could support the hypothesis of a genetic influence on his growth.
By combining these approaches, researchers can gather evidence to support or refute the hypothesis that a delayed onset of puberty contributed to Alex's growth spurt.
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write a DEEP analysis of an animal that stays in an extreme
freezing climate. Discuss the anatomical and physiological features
of the muscular system and skeletal system.
Polar bears are an example of an animal that lives in extreme freezing conditions. Their bodies have unique anatomical and physiological features that enable them to survive and thrive in such conditions.
The skeletal system of a polar bear is adapted to its environment in several ways. Polar bears have a thick layer of fat, known as blubber, that acts as an insulator. The blubber is located between the skin and the muscles, and it helps to keep the bear warm in cold temperatures. Polar bears also have a thick layer of fur that traps air, providing additional insulation. The skeletal system is also adapted for swimming. Polar bears have large, powerful forelimbs that are used for swimming. The forelimbs are also equipped with large, sharp claws that are used for traction on the ice.
The muscular system of a polar bear is adapted for hunting and survival. Polar bears have large, powerful muscles that are used for hunting and capturing prey. Their muscles are also used to maintain body heat in cold temperatures. The muscles are located close to the skin to maximize heat retention. Additionally, polar bears have a unique ability to recycle body heat. They have a system of blood vessels called the "rete mirabile" that allows them to transfer heat from their warm blood to their cold blood, thereby conserving body heat. This system is particularly important when polar bears are swimming in cold water.
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Chymotrypsin is an enzyme, What is it substrate? what does it do? What are some key amino acids found in the active site?
Chymotrypsin is a digestive enzyme that primarily acts in the small intestine to break down proteins into smaller peptides. Its substrate is peptide bonds within proteins.
The main function of chymotrypsin is proteolysis, which is the process of breaking down proteins into smaller peptides. Specifically, chymotrypsin cleaves peptide bonds on the carboxyl side of aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. It exhibits a preference for hydrophobic amino acids in the substrate.
It's important to note that chymotrypsin is just one of the proteases involved in protein digestion, and different enzymes act at different stages of the process to ensure efficient breakdown of dietary proteins into smaller peptides and amino acids for absorption by the body.
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1. Describe the liver on gross inspection. 2. What type of the abnormal intracellular accumulation can be seen in the hepatic
cells?
3. What is the cause of this liver pathology?
4. What type of the abnormal intracellular accumulation can be found in the cardiomyocytes?
5. Describe histologic findings in the heart. Suggest selective staining for the verification of the process.
1. Describe the liver on gross inspection: On gross inspection, the liver is large and pale in colour. There is an accentuation of the lobular architecture, and the cut surface may appear like a coarse nutmeg.
Abnormal intracellular accumulation can take many forms. In the liver, two forms of intracellular accumulation are commonly seen: Steatosis and lipofuscin accumulation.
The cause of these pathological changes is dependent on the type of abnormal accumulation present. For example, steatosis can be caused by metabolic conditions such as obesity or diabetes, while lipofuscin accumulation is caused by oxidative stress from cellular aging.
Cardiomyocytes can accumulate lipofuscin as a result of oxidative stress caused by aging.
Describe histologic findings in the heart. Suggest selective staining for the verification of the process. In the heart, histologic findings that may be present include hypertrophy of the myocardium, interstitial fibrosis, and myocyte loss. To verify these processes, Masson's trichrome staining can be used to stain collagen blue, while cardiomyocytes are stained red with eosin.
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Question 8 1.5 pts Dr Dajer's patient survived after the treatment. He was very confident in his diagnosis that the patient may have inhaled the liquid contrast ma v Ultimately Dr. Dajer determined that he should not v have ordered the original CT scan < Previous
Dr. Dajer's patient survived after treatment. The incorrect order for the original CT scan was determined as the contrast agent was used to enhance the image quality.
In the given statement, Dr. Dajer's patient survived after the treatment. He was very confident in his diagnosis that the patient may have inhaled the liquid contrast. Ultimately Dr. Dajer determined that he should not have ordered the original CT scan.
The term 'Contrast' refers to a substance that radiologists utilize in imaging scans of the human body to improve the quality of the resulting images. It does this by increasing the contrast between two adjacent tissues that would otherwise appear similar.
A contrast agent is used in medical imaging to improve the visibility of internal bodily structures. Contrast-enhanced imaging can be performed by radiography, CT scan, MRI, or even ultrasound. On the other hand, CT (Computed tomography) imaging uses X-rays to generate highly-detailed images of internal structures, allowing physicians to diagnose medical conditions.
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Question 40 1 pts The secretion of ADH results in the formation of a ___________ urine.
The secretion of ADH results in the formation of concentrated urine.
1. Antidiuretic hormone (ADH) is produced by the hypothalamus and released by the posterior pituitary gland.
2. It controls the amount of water reabsorbed by the kidneys into the bloodstream, which ultimately affects urine concentration. ]
3. When there is an excess of water in the bloodstream, ADH secretion is suppressed, and urine production increases.
4. When there is a shortage of water in the bloodstream, ADH secretion is stimulated and urine production is decreased, leading to the formation of concentrated urine.
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please help ASAP
Explain the four stages of external respiration and identify the gradients (driving force) and resistance of each stage.
The four stages of external respiration are pulmonary ventilation, alveolar gas exchange, gas transport in the blood, and systemic gas exchange.
During pulmonary ventilation, the process of breathing, air flows into and out of the lungs, driven by pressure differences between the atmosphere and the lungs. Inhalation occurs when the diaphragm and intercostal muscles contract, increasing the volume of the thoracic cavity and decreasing the pressure, causing air to enter the lungs. Exhalation happens when these muscles relax, decreasing the thoracic volume and increasing the pressure, forcing air out of the lungs.
In the alveolar gas exchange stage, oxygen from the inhaled air diffuses across the thin walls of the alveoli (tiny air sacs) into the pulmonary capillaries, while carbon dioxide diffuses in the opposite direction from the capillaries into the alveoli. This gas exchange occurs due to concentration gradients of oxygen and carbon dioxide between the air in the alveoli and the blood in the capillaries.
Next, in the gas transport stage, oxygen binds to hemoglobin in red blood cells, forming oxyhemoglobin, which is then carried through the bloodstream to the body's tissues. Simultaneously, carbon dioxide is released from the tissues into the bloodstream, where it binds with hemoglobin or dissolves in plasma.
In the final stage, systemic gas exchange, oxygen diffuses from the systemic capillaries into the cells, while carbon dioxide moves in the opposite direction, from the cells into the capillaries. This exchange occurs due to concentration gradients between the tissues and the blood.
Overall, the driving force in each stage of external respiration is the concentration gradient of oxygen and carbon dioxide between the different compartments involved (such as the atmosphere and the lungs, the alveoli and the pulmonary capillaries, the blood and the tissues). Resistance in these stages can occur due to factors like airway constriction, impaired gas diffusion, or reduced blood flow to tissues, which can impede the movement of gases.
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chromosomes are lined up by spindle fibers. nuclear envelope forms around each set of dna. sister chromatids are pulled apart. centromeres move toward the poles of the cell.
Chromosomes line up by spindle fibers, the nuclear envelope forms around each set of DNA, sister chromatids are pulled apart, and centromeres move toward the poles of the cell during anaphase of mitosis.
Anaphase is the fourth phase of mitosis, which begins after the metaphase stage of cell division. During anaphase, chromosomes are pulled apart from the center of the cell to opposite poles by spindle fibers, resulting in sister chromatids. This stage is critical in separating chromosomes equally into daughter cells during cell division.
In this phase, the nuclear envelope reforms around the two groups of chromosomes that form at opposite poles of the cell. The mitotic spindle fibers, attached to the kinetochores of the chromosomes, are shortened, pulling apart the sister chromatids at the centromeres.
As the spindle fibers shorten and move the chromosomes towards the poles, the centromeres move towards the poles of the cell, which effectively pulls the sister chromatids to opposite sides of the cell. This stage marks the beginning of cytokinesis, which is when the cell membrane starts to form in the center of the cell to separate the two new daughter cells.
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1. Draw the pathway that sperm travel from production (where is this?) to exiting the male body. What structures/glands contribute to the production of semen? You may present this as a flow chart or a more realistic drawing.
2. Draw a nephron, including the following structures: Loop of Henle, proximal convoluted tubule, distal convoluted tubule, glomerulus, glomerular capsule.
The sperm pathway from production to exiting the male body is as follows: Testes - Epididymis - Vas deferens - Ejaculatory duct - Urethra. The following structures/glands contribute to the production of semen: Seminal vesicles - Prostate gland - Bulbourethral gland.
The pathway of sperm can be presented as a flowchart or as a more realistic drawing. Here is a detailed explanation of the different structures/glands that contribute to the production of semen:
Testes: The testes are the male gonads that produce sperm and testosterone. Epididymis: The epididymis is a long, coiled tube that lies on the back of each testis.Vas deferens: The vas deferens is a muscular tube that transports sperm from the epididymis to the ejaculatory duct. Ejaculatory duct: The ejaculatory duct is a short, muscular tube that connects the vas deferens to the urethra. Urethra: The urethra is the tube that carries urine and semen out of the body. It is longer in males than in females and is divided into three parts: the prostatic urethra, the membranous urethra, and the spongy urethra.Seminal vesicles: The seminal vesicles are a pair of glands that secrete a fluid rich in fructose and other nutrients. This fluid makes up about 60% of semen volume and provides energy for sperm.Learn more about Bulbourethral gland
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identify and explain the general rules for neurotransmitters
secreted by pre-and postganglionic neurons in the autonomic
division of the nervous system. include the types of receptors they
bind to
Neurotransmitters, which are chemical messengers that transmit signals between neurons, are divided into two broad categories: excitatory and inhibitory neurotransmitters.
Acetylcholine, norepinephrine, and epinephrine are the primary neurotransmitters utilized by the autonomic nervous system. Pre- and postganglionic neurons secrete them. Acetylcholine is released by all preganglionic neurons in both the sympathetic and parasympathetic divisions, as well as by postganglionic neurons in the parasympathetic division. Norepinephrine and epinephrine are both released by postganglionic neurons in the sympathetic division.
Types of receptors that neurotransmitters bind to are as follows:
Acetylcholine: nicotinic and muscarinic receptors.
Norepinephrine and epinephrine: alpha and beta receptors.
The following are the general rules for neurotransmitters that are secreted by pre- and postganglionic neurons in the autonomic division of the nervous system:
Acetylcholine is the primary neurotransmitter utilized by the autonomic nervous system, and it is released by all preganglionic neurons in both the sympathetic and parasympathetic divisions, as well as by postganglionic neurons in the parasympathetic division.
Norepinephrine and epinephrine are both released by postganglionic neurons in the sympathetic division, and they act on alpha and beta receptors. Neurotransmitters that are utilized by the autonomic nervous system bind to specific receptors, and the response that occurs after the neurotransmitter binds is based on the receptor that the neurotransmitter binds to.
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A formerly healthy boy of eleven years has in recent days felt sick with lethargy and fatigue. He has increased urination, but also drinks an unusual amount of water, juice and milk and says he is so thirsty. The parents are very worried because he seems increasingly slacker and in worse shape. They also notice a strange odor from the son's mouth. What disease / condition can this be? Give a short justification for your answer, even if you have several alternative suggestions.
A woman in her forties has for a long time felt slack and inactive. She is worried because she has less stamina. She eats little, but still puts on weight. She freezes more easily than before, and she thinks her skin has become dry and her voice a little hoarse. What disease / condition can this be? What tests are relevant to take? Give a short justification for your answers, even if you have several alternative suggestions.
The disease/condition that a formerly healthy boy of eleven years may be suffering from given the given symptoms is diabetes mellitus. The justification for this diagnosis is as follows:The boy's symptoms include lethargy, fatigue, increased urination, thirst, and a strange odor from his mouth.
These are all classic signs of diabetes mellitus, a condition in which the body cannot regulate its blood glucose levels, resulting in too much glucose in the blood and urine. Increased urination occurs because the kidneys work harder to excrete the excess glucose in the body. The urge to drink more water, juice, or milk is due to dehydration caused by increased urination.
The fruity odor is due to the body breaking down fat for energy because it is unable to use glucose for fuel, resulting in a build-up of ketones. Furthermore, a woman in her forties who has felt slack and inactive for an extended period and has less stamina may be suffering from hypothyroidism. The justification for this diagnosis is as follows:Hypothyroidism is a condition in which the thyroid gland does not produce enough thyroid hormone.
Thyroid hormone is responsible for regulating the body's metabolism. If a person has an insufficient amount of thyroid hormone, their metabolism slows down, resulting in a feeling of lethargy and fatigue. Because the metabolism slows down, even if the individual eats less, they can still put on weight. Dry skin, feeling colder than usual, and a hoarse voice are additional symptoms of hypothyroidism.Tests relevant to take in diagnosing hypothyroidism may include thyroid-stimulating hormone (TSH) test, free thyroxine (T4) test, and total or free triiodothyronine (T3) test. These tests will determine the levels of thyroid hormones in the body.
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A person says "What if biological factors associated with maleness - such as testosterone levels - contribute to aggressive tendencies, which are then fostered and reinforced through social and cultural norms, which then further influence men's testosterone levels? This reciprocal and interactive influence of sex as biological and gender as socialization becomes very difficult to disentangle the root cause of any observed aggression differences between women and men." What is this person making reference to? A. The concept of "doing gender". B. The false dichotomy of sex and gender. C. The invisibility of gender D. The gendering of the X and Y chromosomes.
Biological and social factors, the person challenges the false dichotomy of sex and gender and highlights the need for a more nuanced understanding of human behavior.
The statement highlights the idea that biological factors associated with maleness, such as testosterone levels, may contribute to aggressive tendencies. However, these biological factors are not the sole determinants of aggression. The person suggests that social and cultural norms play a significant role in fostering and reinforcing aggressive behavior in men. This interaction between biological factors and socialization makes it challenging to identify the root cause of observed aggression differences between women and men.
The false dichotomy of sex and gender refers to the misconception that sex (biological differences) and gender (socially constructed roles and behaviors) are strictly separate and independent. This perspective fails to acknowledge the complex interplay between biology and socialization in shaping human behavior.
In this case, the person recognizes that testosterone levels, a biological factor associated with maleness, can influence aggression. However, they also emphasize that social and cultural norms play a crucial role in how aggression is expressed and reinforced within different genders. The reciprocal and interactive influence between biology and socialization makes it difficult to disentangle the root cause of observed aggression differences between women and men.
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7)Define Electronervogram:
8)Define Rheobase:
9)Functions of the blood include:
A.Protective functions
B. Regulatory functions
C.Distribution functions
10)Physiologieal variations of ESR(Erythrocyte sedimentation rate)
A. Age. ESR is less in infants and old people compared to young adults.
B. Sex. ESR is greater in females compared to males.
C.Menstruation. ESR is slightly raised during menstruation in females
D.Pregnancy. ESR is raised in pregnancy from 3rd month to parturition and returns to normal after 3 to 4 weeks of delivery.
11)Normal values of hemoglobin:
A. Men 14-18 g/dI
B.Women 12 to 16 p/dl
C. Newborn 27 g/di
D. Men 18 g/dl
E. Women 16 g/dl
12. Regulatory functions of the blood include:
A.Regulates body temperature by absorbing and distributing heat (e,g, heat loss via skin if hot; heat retention to brain and other vital organs via shunting)
B. Maintains body fluid pH by its many buffers.
C.Maintains adequate, body fluids volume.
D. Carries wastes from all cells to elimination sites(longs for CO2, Kidneys nitrogenous wastes).
E.Carries hormones (chemical signals) from endocrine organs to target tissues.
PLEASE GIVE THE DEFINITIONS Electronervogram and Rheobase AND SOLVE ALL MCQ QUESTIONS FROM 9 TO 12
Electronervogram (ENG): The Electronervogram (ENG) is a medical test used to assess nerve and muscle function by utilizing electrical current.
Rheobase: Rheobase refers to the minimum strength of a stimulus required to excite a specific nerve. It is measured in milliamperes and indicates the threshold for an action potential in the nerve.
Functions of blood include:
A. Protective functions: Blood plays a role in immune defense by carrying white blood cells and antibodies to fight against infections.
B. Regulatory functions: Blood helps regulate body temperature, fluid pH, fluid volume, and transports hormones to target tissues.
C. Distribution functions: Blood transports oxygen, nutrients, waste products, and hormones to various parts of the body.
Physiological variations of ESR (Erythrocyte sedimentation rate):
A. Age: The ESR may vary with age, with higher rates often seen in the elderly.
B. Sex: In some cases, ESR levels may differ between males and females.
C. Menstruation: ESR levels can fluctuate during menstruation.
D. Pregnancy: ESR levels may be elevated during pregnancy.
Normal values of hemoglobin:
A. Men: The normal range of hemoglobin for adult men is typically between 14-18 grams per deciliter (g/dL).
B. Women: The normal range of hemoglobin for adult women is usually between 12-16 g/dL.
Regulatory functions of the blood include:
A. Regulates body temperature by absorbing and distributing heat, such as dissipating heat through the skin when it's hot or retaining heat to vital organs when necessary.
B. Maintains body fluid pH through buffering systems.
C. Maintains adequate body fluid volume.
D. Carries waste products from cells to elimination sites, such as carbon dioxide to the lungs and nitrogenous wastes to the kidneys.
E. Carries hormones from endocrine organs to target tissues, facilitating communication within the body.
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Which of the following is an implication of Hubel and Wiesels strabismus experiments (in which they cut an eye muscle on one side)?
O As long as lebt enters the retina of the alleated the visual sesun will develop normally. O The development of binocular cells in LGN depends on coordinated visual rom both eyes. O Altering Demo cemporal relationship been the moves is one cause long term changes in the visual cortex O There is so much plasticity in the cortex during critical periods that the effect of such manipulations are only short lasting
O As long as visual patterns are forward on the retina of the affected eye. the visual system will develop normally
Hubel and Wiesel's strabismus experiments (in which they cut an eye muscle on one side) revealed that the development of binocular cells in LGN is dependent on coordinated visual input from both eyes.
"The development of binocular cells in LGN depends on coordinated visual from both eyes" is the implication of Hubel and Wiesel's strabismus experiments in which they cut an eye muscle on one side.The experiments revealed that binocular cells in LGN development is reliant on visual input from both eyes. Therefore, if there is a deprivation of visual input in one eye during the critical period, the deprived eye will not develop proper binocular cells, leading to binocular blindness.
The critical period is a time in the early stages of development when specific changes in experience can shape neural circuits. It is worth noting that in these experiments, Hubel and Wiesel found that a cat's visual system might only be changed up to a certain point in development; after that point, plasticity is restricted and the system is considered mature.
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Systematically explain the functional significance of different
parts of the brain
The brain consists of the cerebral cortex, limbic system, basal ganglia, thalamus, brainstem, cerebellum, and corpus callosum, which collaboratively enable cognitive processes, emotional responses, motor control, sensory perception, and information integration.
Different parts of the brain are Cerebral Cortex, Limbic System, Basal Ganglia, Thalamus, Brainstem, Cerebellum, and Corpus Callosum.
The brain is a complex organ that consists of various parts, each with its own unique functions. Here is a systematic explanation of the functional significance of different parts of the brain:
Cerebral Cortex: The cerebral cortex is the outer layer of the brain and is responsible for higher cognitive functions such as thinking, reasoning, perception, and voluntary movement. It is divided into four lobes: frontal, parietal, temporal, and occipital. Each lobe has specific roles, for example:
Frontal lobe: It is involved in decision-making, problem-solving, and motor control.
Parietal lobe: It processes sensory information, spatial awareness, and perception.
Temporal lobe: It plays a role in memory, language processing, and auditory perception.
Occipital lobe: It is primarily responsible for visual processing.
Limbic System: The limbic system is a group of structures located deep within the brain and is involved in emotion, memory, and motivation.
Key components include the hippocampus (memory formation), amygdala (emotion and fear processing), and hypothalamus (regulation of basic drives like hunger, thirst, and sexual behavior).
Basal Ganglia: The basal ganglia are a group of structures involved in motor control, procedural learning, and habit formation. They help initiate and regulate voluntary movements and are also implicated in Parkinson's disease and other movement disorders.
Thalamus: The thalamus acts as a relay station for sensory information, directing signals to the appropriate areas of the cerebral cortex for processing. It is crucial for sensory perception, attention, and consciousness.
Brainstem: The brainstem is the oldest and most primitive part of the brain, responsible for vital functions necessary for survival, including regulating heartbeat, breathing, and maintaining basic levels of consciousness. It comprises the midbrain, pons, and medulla oblongata.
Cerebellum: The cerebellum is located at the back of the brain, below the cerebral cortex. It plays a critical role in coordinating and fine-tuning motor movements, maintaining balance and posture, and motor learning.
Corpus Callosum: The corpus callosum is a bundle of nerve fibers that connects the left and right hemispheres of the brain. It facilitates communication and information exchange between the two hemispheres, enabling integration of sensory and motor functions.
It's important to note that this is a simplified overview, and each brain region interacts with others to support complex cognitive and physiological processes.
The brain's functional significance arises from the intricate connections and interactions between these various parts, allowing for the integration of information, control of bodily functions, and the basis of our cognitive abilities.
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Question Two Answer both parts, (i) and (ii). (i) Describe how isolated tissue experiments can be used to detect the following type of receptor-ligand behaviour: agonism, partial agonism, antagonism, irreversible antagonism 110 Marks) (ii) Outline a structure-activity profile for the fluoroquinoline group of antibacterial agents. Your answer should also describe the attractions of incorporation of fluorine as a substituent in the molecular structures of APIs/prospective APIs. [10 Marks)
The isolated tissue experiments have been used to detect the following receptor-ligand behavior. Here’s how: Isolated Tissue experiments and Agonism.
Agonism is detected through measuring the contraction of an isolated tissue sample when the sample is exposed to a particular receptor ligand. Here, the receptor agonist's concentration and the agonist's potency is increased until the tissue reaches maximum contraction. Isolated Tissue experiments and Partial AgonismPartial agonism is detected in a similar way to agonism. Here the isolated tissue samples are treated with two types of drugs. The tissue sample’s response is then measured in terms of their maximum possible response, as well as the response of the tissue sample’s agonist.
Antagonism is detected by exposing an isolated tissue sample to an agonist and then measuring the antagonists’ ability to compete with agonist’s effects. The tissue’s response to the agonist is then compared to the response elicited by the agonist in the presence of the antagonist. Isolated Tissue experiments and Irreversible Antagonism An irreversible antagonist is detected by allowing the antagonist to act on a tissue sample for an extended period of time, after which the agonist is introduced. If the agonist fails to elicit the expected response, then the presence of an irreversible antagonist can be inferred.
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For an estimation of microbial population experiment, you obtained the following results: A. 1000X dilution with 0.1 mL sample volume - 470 colonies B. 10000X dilution with 0.1 mL sample volume - 250 colonies C. 100000X dilution with 0.1 mL sample volume - 100 colonies D. 1000000X dilution with 0.1 mL sample volume −12 colonies For each set of results, determine if the samples are countable plates, and for only the countable plates, calculate the CFU/mL for those plates. For plates that are not countable, please state that and do not perform the calculation (please note that calculating the CFU/mL for a plate that is not countable will be marked as incorrect).
To measure the microbial population, the experiment counts the number of colonies on the plates. The conventional approach states that the countable plates are those with 30 to 300 colonies.
Using this criterion, we can see that plates A, B, and C are countable plates since they have 470, 250, and 100 colonies, respectively. Plate D is not countable since it has only 12 colonies.
To calculate the CFU/mL for each of the countable plates, we need to use the following formula:
CFU/mL = (number of colonies/sample volume) x (1 / dilution factor)
For plate A, the dilution factor is 1000X, and the sample volume is 0.1 mL.
Therefore, the CFU/mL = (470 / 0.1) x (1 / 1000) = 4.7 x 10^6 CFU/mL
For plate B, the dilution factor is 10,000X, and the sample volume is 0.1 mL.
Therefore, the CFU/mL = (250 / 0.1) x (1 / 10,000) = 2.5 x 10^5 CFU/mL
For plate C, the dilution factor is 100,000X, and the sample volume is 0.1 mL.
Therefore, the CFU/mL = (100 / 0.1) x (1 / 100,000) = 1 x 10^5 CFU/mL
Plate D is not countable, so we cannot calculate the CFU/mL for this plate.
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PLEASE HELP ME ANSWER ALL OF THE FOLLOWING ASAP AND I WILL THUMBS UP YOUR RESPONSE!!!!! Which structure cannot be visualized in this anatomical model? Greater trochanter (B) Lesser trochanter Neck Head Which structure cannot be visualized in this anatomical model? Supraspinous fossa (B) Acromion (C) Spine of scapula (D) Subscapular fossa The fingers are palpating the A. Scaphoid B) Radius UIna D) 5 th metacarpal What region of the spine is this vertebra from? Cervical Thoracic Lumbar Sacral
The thoracic region provides stability to the spine and supports the upper body.
The structure that cannot be visualized in this anatomical model is Neck Head. The neck head is an area located in the proximal area of the femur bone. This region is the point of articulation between the thigh bone and the hip. The neck head has a pivotal role in the function of the hip joint. It connects the long bone of the thigh to the pelvis and supports the weight of the body.
The neck head is an area that is susceptible to injury, specifically in the elderly population who suffer from osteoporosis and arthritis. Injuries to this area can lead to hip fractures and impair mobility. The structure that cannot be visualized in this anatomical model is Supraspinous fossa.
The supraspinous fossa is a depression on the scapula that is located above the spine of the scapula. It is a small area where the supraspinatus muscle attaches. This muscle is essential for shoulder function, specifically for shoulder abduction. A tear in the supraspinatus muscle can lead to pain and a decrease in shoulder function.
The vertebra is from the Thoracic region of the spine. The thoracic spine is located between the cervical and lumbar regions and is made up of twelve vertebrae. This region is characterized by the presence of ribs that articulate with the vertebrae.
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discuss the use of dietary supplements. in your answer you should apply your knowledge of what you have learnt in the module to discuss why patients use dietary supplements, evidence for the beneficial effects and evidence of toxic or other detrimental effects
Dietary supplements are defined as products taken orally that contain any ingredient intended to supplement the diet. They come in different forms, such as pills, capsules, tablets, powders, and liquids.
Patients use dietary supplements for several reasons, including the maintenance of good health, treatment of specific conditions, prevention of diseases, and general well-being. However, the use of dietary supplements has some beneficial effects and also has some toxic or other detrimental effects.
In terms of beneficial effects, many dietary supplements contain ingredients that offer potential health benefits. For instance, dietary supplements containing folic acid are recommended for pregnant women as they can help to prevent neural tube defects in the developing fetus. Calcium and vitamin D supplements have been shown to support strong bones and prevent osteoporosis.
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For the situation in #1B, what happens in each of the following parameters? (This question is NOT a MC question, but parts a-d. For example, in part a, will cardioinhibitory center or cardioacceleratory center be stimulated? Highlight the correct answer in color. Same for b through d.)
a.Cardioinhibitory center OR cardioaccelatory center is stimulated
b.Increase OR decrease in cardiac output
c.Increase OR decrease respiratory rate
d.More OR less oxygen getting to tissues
For the situation in #1B, Cardioacceleratory Center is stimulated, and the cardiac output increases. The answer is (C).
There will also be an increase in the respiratory rate, resulting in more oxygen getting to the tissues. A cardioacceleratory center stimulates the heart to beat more quickly, resulting in an increase in heart rate and cardiac output. On the other hand, a cardioinhibitory center slows the heart rate by inhibiting the cardiovascular center, decreasing heart rate and cardiac output.
The Cardioacceleratory center will be stimulated in situation #1B. Therefore, the answer for part a is cardioacceleratory center is stimulated. There will be an increase in the cardiac output, so the answer for part b is an Increase. The answer for part c is Increase because the respiratory rate increases. There will be more oxygen getting to tissues in this case, so the answer for part d is more oxygen getting to tissues.
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Why do anti-doping organizations all establish a minimum threshold for cannibinoid concentration in samples even though they are banned?
A. To not punish athletes for passive ingestion/secondhand inhalation
B. The threshold reflects the legal limit to operate a motor vehicle.
C. Below a certain threshold, cannabinoids have no effect.
D. Marijuana is legal everywhere if the ingestion of the drug is low enough.
Option A is correct. Anti-doping organizations all establish a minimum threshold for cannabinoid concentration in samples even though they are banned to not punish athletes for passive ingestion/secondhand inhalation.
What is an anti-doping organization? Anti-doping organizations are organizations created to keep sports competitions fair and free from doping. The goal is to provide athletes with a level playing field by ensuring that no one has an unfair advantage.
What are cannabinoids? Cannabinoids are a group of substances that include natural and synthetic compounds. Cannabinoids are similar to chemicals naturally produced by the body and are involved in appetite, pain, mood, and memory. THC, the psychoactive component of marijuana, is a cannabinoid.
Why is the minimum threshold for cannabinoid concentration in samples established? Anti-doping organizations all establish a minimum threshold for cannabinoid concentration in samples even though they are banned to not punish athletes for passive ingestion/secondhand inhalation. A positive test result may be the result of passive exposure to smoke or vapor, and the threshold allows for this possibility.
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If you could artificially modify the membrane resting potential from -70 mV to +70 mV, what will the sodium ions (Na+) net movement be?
A. Na+ will enter the cell without modifying the voltage.
B. Na+ will enter the cell following its concentration gradient.
C. Na+ will exit the cell even against the concentration gradient.
D. Na+ will not move from the compartments.
What will happen to the resting membrane potential if more K+ (potassium) channels are opened?
A. The resting membrane potential will move closer to zero (depolarize).
B. The resting membrane potential will stay close to +20 mV.
C. The resting membrane potential will stay around -60 mV.
D. The resting membrane potential will hyperpolarize.
Of the following graded potentials, which one is produced by efflux of potassium?
A. end-plate potential.
B. excitatory postsynaptic potential (EPSP).
C. inhibitory postsynaptic potential (IPSP).
D. organ of Corti receptor potential.
What type of receptor is responsible for the generation of a local potential at the organ of Corti?
A. it is a TRP1 receptor (transitory receptor potential).
B. it is an ionotropic receptor.
C. it is a MET receptor (mechanoelectrical transducer).
D. it is a proprioceptor similar to the muscle spindle.
What do drugs of addiction and natural behaviors share?
A. drugs of addiction increase serotonin while natural behaviors increase dopamine in the nucleus accumbens.
B. they all increase acetylcholine in the striatum.
C. Drugs of addiction and natural behaviors have opposite effects in dopamine release.
D. they all increase dopamine in the nucleus accumbens.
Regarding environmental influences on weight
A. the influence of infection has been disproven.
B. social influence is mostly from the family.
C. smoking increases appetite.
D. sleep loss increases appetite.
If you could artificially modify the membrane resting potential from -70 mV to +70 mV, the sodium ions (Na+) net movement will be Na+ will enter the cell following its concentration gradient.
The resting membrane potential will hyperpolarize is what will happen to the resting membrane potential if more K+ (potassium) channels are opened.
At synapses, potassium ions efflux from the cell leads to hyperpolarization or inhibitory postsynaptic potential. The efflux of positively charged potassium ions leads to more negative potential which makes it difficult for positively charged ions to enter the cell.
It is a MET receptor (mechanoelectrical transducer) that is responsible for the generation of a local potential at the organ of Corti.
They all increase dopamine in the nucleus accumbens is
Regarding environmental influences on weight Sleep loss increases appetite. is the correct option.
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Which of the following statements are false? Weak junctions between endothelial cells of the 8BB allow passage of substances from the circulation to the brain. Dysregulation of BBB function is implicated in several neurologic diseases, including multiple sclerosi․ Pericytes are located outside of the capillary walls and closely associate with endothelal cells: The BBB protects the brain from toxins What is a Nervous System?
The following statement is false: Weak junctions between endothelial cells of the BBB allow passage of substances from the circulation to the brain.
The statement 'Weak junctions between endothelial cells of the BBB allow passage of substances from the circulation to the brain' is false since the tight junctions between the endothelial cells of the BBB prevent substances in the bloodstream from entering the brain. BBB, or Blood-Brain Barrier is a selectively permeable, extremely tight, and semi-permeable barrier that separates circulating blood from the brain and extracellular fluid of the central nervous system (CNS).
The BBB is composed of three main components:Endothelial cells Pericytes Astrocytes BBB is critical for maintaining brain homeostasis and function by regulating the entry and exit of molecules. Dysregulation of BBB function has been linked to various neurological disorders such as multiple sclerosis.
The nervous system is made up of two main parts: The central nervous system (CNS) and the peripheral nervous system (PNS).The CNS consists of the brain and spinal cord, which receive, process, and integrate information, while the PNS consists of the nerves that connect the CNS to various parts of the body.
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How does this mutation affect homeostasis and feedback systems in the body? You must reference AT LEAST 2 body systems.
Mutations can have a significant impact on homeostasis and feedback systems in the body. Homeostasis refers to the ability of the body to maintain a stable internal environment, while feedback mechanisms are mechanisms that regulate the internal environment by providing information to the body about changes in the environment.
These mechanisms are essential for the proper functioning of the body.In the body, the nervous and endocrine systems are two critical systems that play a significant role in regulating homeostasis. Mutations can affect these systems and impact homeostasis. Let's take a look at how these mutations can affect these systems:Nervous System:Mutations that impact the nervous system can lead to disruptions in homeostasis. The nervous system controls all voluntary and involuntary movements in the body, including those that regulate homeostasis. Any mutation that impacts the functioning of the nervous system can disrupt these movements and lead to imbalances in the body.For example, a mutation in the genes that regulate neurotransmitters could lead to a decrease in the number of neurotransmitters produced.
This could lead to a decrease in the ability of the nervous system to regulate homeostasis.Endocrine System:Mutations that impact the endocrine system can also lead to disruptions in homeostasis. The endocrine system is responsible for producing hormones that regulate various processes in the body. These hormones are essential for maintaining homeostasis and ensuring that the body functions properly.A mutation in the genes that regulate hormone production could lead to an imbalance in hormone levels. This imbalance could cause the body to malfunction and lead to various health problems.To summarize, mutations can affect homeostasis and feedback systems in the body. The nervous and endocrine systems are two critical systems that play a significant role in regulating homeostasis. Mutations that impact these systems can lead to disruptions in homeostasis and imbalances in the body.
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Which carbon-to-hydrogen mass ratio is possible for another compound composed only of carbon and hydrogen? you may need to round your answer to three significant figures before evaluating your answer.
The carbon-to-hydrogen mass ratio for another compound composed only of carbon and hydrogen can vary. However, if we assume that the compound is hydrocarbon-based, the possible carbon-to-hydrogen mass ratios can be determined by considering the molecular formulas of different hydrocarbons.
1. Determine the molecular formula of the hydrocarbon compound. Let's assume it is CₓHᵧ, where x represents the number of carbon atoms and y represents the number of hydrogen atoms.
2. Calculate the molar mass of carbon (12.01 g/mol) and hydrogen (1.008 g/mol).
3. Calculate the total molar mass of the compound by multiplying the number of carbon atoms (x) by the molar mass of carbon and the number of hydrogen atoms (y) by the molar mass of hydrogen. The total molar mass is given by: (12.01 * x) + (1.008 * y) g/mol.
4. Calculate the carbon-to-hydrogen mass ratio by dividing the molar mass of carbon (12.01 * x) by the molar mass of hydrogen (1.008 * y): (12.01 * x) / (1.008 * y).
To round the answer to three significant figures, you would need to round the x and y values to three significant figures before calculating the ratio.
In summary, the carbon-to-hydrogen mass ratio for a compound composed only of carbon and hydrogen can vary depending on the molecular formula.
To calculate the ratio, determine the molar mass of carbon and hydrogen, calculate the total molar mass of the compound, and divide the molar mass of carbon by the molar mass of hydrogen. Remember to round your answer to three significant figures.
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muscle origin insertion synergist(s) antagonist(s) action
Iliocostalis (lateral)
Omohyoid – superior belly
Omohyoid – inferior belly
Spinalis (medial)
Flexor hallucis longus
Semimembranosus
Semitendinosis
Zygomaticus minor
Vastus medialis
Longissimus (middle)
Splenius capitis
External oblique
Mentalis
The muscle origin, insertion, synergists, antagonists, and actions for the listed muscles .
Iliocostalis (lateral)
Origin: Iliac crest, sacrum, and lumbar spinous processes
Insertion: Angles of the lower ribs
Synergists: Longissimus and spinalis muscles
Antagonists: Rectus abdominis and external oblique muscles
Action: Extension and lateral flexion of the vertebral column
Omohyoid – superior belly
Origin: Intermediate tendon attached to the superior border of the scapula
Insertion: Inferior border of the hyoid bone
Synergists: Digastric and sternohyoid muscles
Antagonists: Sternocleidomastoid and stylohyoid muscles
Action: Depresses and retracts the hyoid bone
Omohyoid – inferior belly
Origin: Superior border of the scapula
Insertion: Intermediate tendon attached to the clavicle
Synergists: Sternohyoid and sternothyroid muscles
Antagonists: Trapezius and levator scapulae muscles
Action: Depresses and retracts the hyoid bone
Spinalis (medial)
Origin: Spinous processes of the upper thoracic and lower cervical vertebrae
Insertion: Spinous processes of the upper cervical vertebrae
Synergists: Longissimus and iliocostalis muscles
Antagonists: Rectus abdominis and external oblique muscles
Action: Extension and lateral flexion of the vertebral column
Flexor hallucis longus
Origin: Posterior fibula and interosseous membrane
Insertion: Base of the distal phalanx of the great toe
Synergists: Tibialis posterior and flexor digitorum longus muscles
Antagonists: Extensor hallucis longus and extensor digitorum longus muscles
Action: Flexion of the great toe
Semimembranosus
Origin: Ischial tuberosity
Insertion: Medial condyle of the tibia
Synergists: Semitendinosus and biceps femoris muscles
Antagonists: Quadriceps femoris muscles
Action: Flexion of the knee and extension of the hip
Semitendinosus
Origin: Ischial tuberosity
Insertion: Proximal part of the medial surface of the tibia
Synergists: Semimembranosus and biceps femoris muscles
Antagonists: Quadriceps femoris muscles
Action: Flexion of the knee and extension of the hip
Zygomaticus minor
Origin: Lateral infraorbital margin
Insertion: Upper lip
Synergists: Zygomaticus major and levator labii superioris muscles
Antagonists: Depressor anguli oris and depressor labii inferioris muscles
Action: Elevates the upper lip, contributing to smiling and facial expression
Vastus medialis
Origin: Linea aspera of the femur
Insertion: Medial aspect of the patella and tibial tuberosity
Synergists: Vastus lateralis, vastus intermedius, and rectus femoris muscles
Antagonists: Hamstring muscles (e.g., biceps femoris)
Action: Extension of the knee
Longissimus (middle)
Origin: Transverse processes of the thoracic and upper lumbar
Splenius capitis:
Origin: Nuchal ligament, spinous processes of C7-T6 vertebrae
Insertion: Mastoid process and lateral part of the superior nuchal line
Synergists: Semispinalis capitis and longissimus capitis muscles
Antagonists: Sternocleidomastoid and levator scapulae muscles
Action: Extension, lateral flexion, and rotation of the head
External oblique:
Origin: External surfaces of the lower eight ribs
Insertion: Linea alba, pubic tubercle, and anterior half of the iliac crest
Synergists: Internal oblique and transversus abdominis muscles
Antagonists: Erector spinae and quadratus lumborum muscles
Action: Bilateral contraction flexes the vertebral column and compresses the abdominal contents, while unilateral contraction produces ipsilateral lateral flexion and contralateral rotation of the trunk
Mentalis:
Origin: Incisive fossa of the mandible
Insertion: Skin of the chin
Synergists: Depressor labii inferioris and platysma muscles
Antagonists: Levator labii superioris and levator anguli oris muscles
Action: Elevates and wrinkles the skin of the chin, producing a pouting or wrinkling expression
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