Which of the following conditions would activate the unfolded protein response? (check all that apply)
Group of answer choices
a. reduction in receptor-mediated endocytosis
b. synthesis of many extra secreted proteins.
c. mutation of a factor critical for degradation of proteins in the lysosome
d. mutation of a factor important for protein folding in the ER

Answer:

b. synthesis of many extra secreted proteins.

c. mutation of a factor critical for degradation of proteins in the lysosome

d. mutation of a factor important for protein folding in the ER

The conditions that would activate the unfolded protein response are:

The unfolded protein response may be defined as a cellular stress response related to the endoplasmic reticulum stress. It is a mechanism through which the accumulation of misfolded protein is induced.

Unfolded protein response gats are activated when there is any mutation or alteration that takes place in the ER, and sometimes lysosomes. Because these are both organelles that mediate the protein trafficking throughout the cell.

Therefore, the conditions that would activate the unfolded protein response are statements (b), (c), and (d).

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