The enzyme dihydrofolate reductase (DHFR) normally resides in the cytosol, and it can be imported into mitochondria by appending a mitochondrial signal sequence. However, when this modified DHFR is incubated with methotrexate, which is a substrate analog that binds tightly to the active site, the modified DHFR is no longer imported. Propose an explanation for this finding.
Required:
a. Consider a transmembrane protein that spans the inner nuclear membrane. Suggest a pathway by which such a protein could reach its destination.
b. Clathrin can assemble with multiple types of adaptors to create coated vesicles. Explain why this multiplicity of adaptors is useful to the cell
Answer:
Within the mitochondria, the import takes place post-translationally. The imported protein must be in an unfolded condition so that it can go through the mitochondria's import machinery. In the existence of methotrexate, the bound DHFR moiety remains in the folded state, and thus, stays on the surface of mitochondria.
It is witnessed that the presequence must be of the length of 55 amino acids to cover both the membranes of mitochondria and must be of about sixty amino acids length to associate with the mhsp70. If the presequence of this methotrexate bound DHFR is of seventy-five amino acids in length, it can associate with mhsp70 within the matrix, to initiate the ATP reliant import within the mitochondria. Due to the presence of various endocytic and intracellular sorting signals, multiple adaptors are essential.
Which of the following is NOT an
ecological effect of mining?
A. habitat disruption
B. loss of biodiversity
C. acid mine drainage
D. increased biodiversity
d is correct
..................
^_^
One way to think about the importance of biodiversity is simply to think in terms of natural capital: the roles that genes, species, ecosystems, and ecological processes play in supporting human society and a healthy biosphere. What are benefits provided by biodiversity?
Answer and Explanation:
Biodiversity composes of different species living in a certain restricted area. It is the variability of living beings in a natural environment, involving all the species on the planet and their genetic material. This variety includes all plants, animals, fungus, and microorganisms living in a certain place, their genetic variability, and the ecosystems these species form.
Ecosystems include all the biotic, physical, and chemical components of nature, continuously interacting and depending on each other. The ecosystem is composed of living and non-living things that interact and depend on each other. These are the biotic and abiotic factors.
Biodiversity, in equilibrium with abiotic factors, provides ecosystem services, which are important for the maintenance of all forms of life, including human beings.
Ecosystem services
When talking about ecosystem services, we are referring to the benefits that ecosystems provide us. There are four types of ecosystem services:
Provision or supply:These are the products obtained by nature to be used or consumed, directly or with previous processing. Among them, we might mention food, clear freshwater, fertile soils, geotic materials, raw materials (that can be used for clothing, construction), renewable fuels, biochemical compounds, pharmacological/medicinal resources, among others.
Regulation:Refers to ecological processes that improve life. Among others, we might mention climate regulation, CO² absorption, water purification, air purification, erosion control, natural disaster avoidance such as flooding, soil fertility maintenance, waste recycling, pests/plagues control, etc.
Cultural:Refers to not the material benefits. Ecosystems provide a recreational place or area to spend time and learn. They provide a spiritual/religious space, are a source of inspiration. Ecosystems are cultural patrimony and the source of scientific knowledge.
Question 12 of 15
A force is a push or pull.
Answer:
True
Explanation:
A force is a push or pull against something or someone
Advantages and disadvantages of physical barriers in the immune system
Explanation:
advantages:Physical barriers play an important role in preventing microbes from reaching tissues that are susceptible to infection. At the cellular level, barriers consist of cells that are tightly joined to prevent invaders from crossing through to deeper tissue.
Physical barriers play an important role in preventing microbes from reaching tissues that are susceptible to infection. At the cellular level, barriers consist of cells that are tightly joined to prevent invaders from crossing through to deeper tissue.
What is immune system?Immune system is a large network of organs, white blood cells, proteins (antibodies) and chemicals. This system works together to protect you from foreign invaders (bacteria, viruses, parasites, and fungi) that cause infection, illness and disease.
Disadvantages of physical barriers in the immune system is causing immuno deficiency disease.
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what is uterus?
what is the function of it in human body
Answer:
Explanation:
The uterus is a hallow and flattened muscular organ that is the home to developing fetus.It is divide into three parts:fundus, body, and cervix.
Its functions are:
1.to regulate menstural cycle throughout the reproductive period.
2.to pass the sperms towards fallopian tubes for fertilization.
3.to provide site for embedding zygote.
4.to expel fetus through cervix at the time of birth.
Answer:
1. uterus is also known as the womb.
2.it helps to form a child (that is inside the womb) when the sperm is disposed inside the womb
Plz someone help. This is due tonight!!!! I will give brainiest if you fill it out and NO LINK!!
Answer: I am not sure i will try to figure out
Explanation:
In humans, hemophilia is a sex-linked recessive trait. If a male who has hemophilia marries a female with
normal blood clotting, what percent of the males will have the disease
A- 0 males= 0% of the males
B- 1 male= 50% of the males
C- 2 males= 100% of the males
D- 3 males= 100% of the males
C- 2 males. 100% of males. I don't know but try using a punnet square to figure it out yourself :)
An enzyme that breaks DNA, dispels the tension, and reseals the strand ahead of a DNA replication growing fork is called a(n):
Answer:
Topoisomerase
Explanation:
Topoisomerases are enzymes that produce changes in the topology of the DNA during replication, transcription, traduction, or reparation processes. They can cut one or both strands and in order to relieve torsional stresses in the supercoiled structure of DNA. With this, they help to maintain the chromosome's integrity. There are two types of topoisomerases: topoisomerase I (it cuts only one strand of DNA) and topoisomerase II (it is able to cut both strands of DNA).
How many protons, neutrons, and electrons are found in a neutral atom of lithium-8?
Answer:
Three Protons
Four neutrons
Three electrons are found in a neutral atom of lithium 8
BRAINLIEST
PLZZ HELP ME !!!
Answer:
the answer is in picture
according to the article why is it important for pikas to find cool habitats
!!20 POINTS!!
Human use a (an) ____________ circulatory system to remove waste.
A. Open
B. Closed
C. Capillariy
D. Continuous
Answer:
its continuous
Beatrice’s science teacher gave her an unknown substance to identify based on its properties. After a few tests, Beatrice listed her observations in a chart.
reflects light very well
warms up in my hand
flattens out when hit with a hammer
conducts electricity
Which kind of substance does Melinda have?
A. metalloid
B. nonmetal
C. metal
D. noble gas
convention cells hbnmb,
Answer:
convention cells
Explanation:
In the field of fluid dynamics, a convection cell is the phenomenon that occurs when density differences exist within a body of liquid or gas. These density differences result in rising and/or falling currents, which are the key characteristics of a convection cell. When a volume of fluid is heated, it expands and becomes less dense and thus more buoyant than the surrounding fluid. The colder, denser part of the fluid descends to settle below the warmer, less-dense fluid, and this causes the warmer fluid to rise. Such movement is called convection, and the moving body of liquid is referred to as a convection cell. This particular type of convection, where a horizontal layer of fluid is heated from below, is known as Rayleigh–Bénard convection. Convection usually requires a gravitational field, but in microgravity experiments, thermal convection has been observed without gravitational effects.
what kind of graph is this?
Answer:
Explanation:
financial chart
g In transcription, the 3'-hydroxyl group of the growing RNA strand: Group of answer choices NONE OF THESE binds to the 5' ribose. attacks the outermost phosphorous group of the incoming nucleotide. ALL OF THESE attacks the 5' hydrogen of the incoming nucleotide. interacts with a positively charged metal ion in the active site.
Answer:
attacks the outermost phosphorous group of the incoming nucleotide.
Explanation:
Transcription is the biological process where RNA is formed. As you may already know, RNA is an extremely important nucleic acid for genetic processes and the production of proteins. The transcription has three steps that are called start, elongation and end. In the elongation phase, the RNA strand is growing, at this time, RNA polymerase, which is the enzyme responsible for RNA elaboration, places the nucleotides, in the RNA strand, in the 5' - 3' direction. This enzyme causes the hydroxyl, which makes up the nucleotide at the 3' end of the forming RNA, to attack the phosphorus present in the incoming ribonucleotide.
As with any major scientific discovery, the previous work of many different scientists help contribute to final conclusions. Which of the following scientists' work did not contribute to the discovery of the structure of the DNA molecule? A Gregor Mendel B Linus Pauling C Erwin Chargaff D Rosalind Franklin
A
AExplanation:
AExplanation:Gregor Mendel is generally regarded as the father of genetics due to his three(3) laws of genetics. Non of his work alluded to the existence of the DNA molecules( i.e. the major constituent of genes) let alone its structure.
A fruit fly of genotype B R/b r is testcrossed with b r/b r. In 84 percent of the meioses, there are no chiasmata between the linked genes; in 16 percent of the meioses, there is one chiasma between the genes. What proportion of the progeny will be B r/b r
Answer:
4 percent (4%)
Explanation:
A single crossover occurs between two (non-sister) chromatids belonging to homologous chromosomes. In this case, 16 percent of the meioses have a single crossover, thereby it will produce 8 percent of the chromosomes with the original (parental) combination in the progeny and the remaining 8 percent should be recombinants. From this result, it is reasonable to conclude that half of these recombinants should be 'Br' (and the other remaining 4 percent should be recombinants 'bR'), and therefore the answer is 4 percent (4%).
A scientist discovers a new organism and is trying to classify it. Which observations would most likely indicate that
the organism is an animal?
It is multicellular and can move itself from place to place,
It is heterotrophic and unicellular.
It makes food from sunlight and is eukaryotic.
It is prokaryotic and can move itself from place to place.
Answer:
B) It is heterotrophic and unicellular.
Hope This Helped!
Answer:
It is multicellular and can move itself from place to place.
Explanation:
i took the test the other answer is wrong
Help please
What factors can influence the carrying capacity of an ecosystem?(CHOOSE ALL THAT APPLY)
A The number of predators
B The amount of available food
C The amount of water
D The amount of sunlight
E The water clarity of an aquatic ecosystem
Answer:
ABCD
Explanation:
A change in a gene or chromosome that causes a new trait to be inherited is called a
Answer:
I think the answer is a gene mutation.
Explanation:
A gene mutation is a change in one or more genes.
For the following question, match the key event of meiosis with the stages listed below. I. Prophase I V. Prophase II II. Metaphase I VI. Metaphase II III. Anaphase I VII. Anaphase II IV. Telophase I VIII. Telophase II Centromeres of sister chromatids disjoin and chromatids separate.
Answer:
VII. Anaphase II
Explanation:
During metaphase II, fibers of the spindle apparatus drive chromosomes to the cell equatorial plane, where they line up. Sister chromatids are holden together until they reach Anaphase II, during which specialized enzymes break the bonds between chromatids and separate them. Each chromatid migrates to one of the poles. In telophase II, the new chromosomes are already in the corresponding poles, and the nuclear membrane forms again in each pole
3. Round shells is incompletely dominant to square shells, the heterozygous combination is a pointed shell. Smelly
shell's is an X-linked trait and recessive. A pointed shell smelly shelled male is crossed with a round
heterozygous non-smelly shelled female. What's the phenotype of their offspring?
Answer:
2/16 rounded not smelly females, RRX+X-
2/16 pointed not smelly females, RrX+X-
2/16 rounded smelly females, RRX-X-
2/16 pointed smelly females, RrX-X-
2/16 rounded not smelly males, RRX+Y
2/16 pointed not smelly males, RrX+Y
2/16 rounded smelly males, RRX-Y
2/16 pointed smelly males, RrX-Y
Explanation:
Available data:
RR round shellrr square shellRr Pointed shellX+ is dominant and codes for not smellyX- is recessive and codes for SmellyCross: A pointed smelly shelled male with a round heterozygous non-smelly female
Parentals) Rr X-Y x RRX+X-
Gametes) RX-, RY, rX-, rY
RX+, RX+, RX-, RX-
Punnett square) RX- rX- RY rY
RX+ RRX+X- RrX+X- RRX+Y RrX+Y
RX+ RRX+X- RrX+X- RRX+Y RrX+Y
RX- RRX-X- RrX-X- RRX-Y RrX-Y
RX- RRX-X- RrX-X- RRX-Y RrX-Y
F1) 2/16 bivalves are expected to be rounded not smelly females, RRX+X-
2/16 bivalves are expected to be pointed not smelly females, RrX+X-
2/16 bivalves are expected to be rounded smelly females, RRX-X-
2/16 bivalves are expected to be pointed smelly females, RrX-X-
2/16 bivalves are expected to be rounded not smelly males, RRX+Y
2/16 bivalves are expected to be pointed not smelly males, RrX+Y
2/16 bivalves are expected to be rounded smelly males, RRX-Y
2/16 bivalves are expected to be pointed smelly males, RrX-Y
BRAINLIEST
CAN SOMEONE PLZ HELP ME!!
Explanation:
I’m pretty sure it’s phenotypes
Charles Darwin developed the theory of evolution. Scientific laws and theories are different from one another. Which of the following best describes the differences between scientific laws and theories?
Answer:
C
Explanation:
IM BiuLt DIFFRENT
Certain species of blind fish living in perpetual darkness in the ocean depths have evolved from ancestors that could see. Research indicates that the brain centers for vision in these fish is degenerating, whereas the brain centers controlling other senses are enlarging. What might be the MOST probable reason for the loss of vision in these fish
Answer:
Explanation:
Evolution for lack of light. If there is no reason for it you lose the ability but it strengthens other senses. It's compensation. The need to tell if the temperature has increased because of something nearby or ability to feel miniscule movement will increase to compensate for that lack of sense.
I need help, please help me
Answer:
False for both
Explanation:
In the first one you can see the red line has a greater slope. In the second you can see the yellow line acts as an outlier
Hope this helps
In the following choices, the one that is NOT a function of the skeletal
system is
O protect organs
make red blood cells
transport blood cells
O provide shape and support
Answer:
I'm pretty sure it's transport blood cells
approximately how far away is the epicenter for an earthquake if the p-waves arrive three minutes 20 seconds before the S Wave
Answer:
Only P-waves were recorded at seismic station C because P-waves travel At different avival times
Explanation:
....