Antibiotic resistant bacteria are becoming more and more prevalent, leaving us in desperate need of novel antimicrobial compounds to replace the drugs that are now obsolete in our hospitals and medical clinics. A high throughput screen of 700,000 compound library has allowed you to identify one molecule capable of killing extensively drug resistant tuberculosis at concentrations 1000X lower than currently used therapeutics. The only problem is, you don't know the molecular target. Develop an experimental strategy to identify the molecular target of your new antibiotic. Make sure to use some of the techniques described in the chapters covered throughout Units 1-6, and be creative. There isn't one correct answer!'

Answers

Answer 1

Answer:

Explanation:

We know the molecules equipped for killing broadly drug-resistant tuberculosis. This requires that we build up an experimental test system to distinguish the molecular target of your new antibiotic.

These steps include:

Gather proteomics data of tuberculosis and gather structural data of all proteins inside it.  

At that point perform molecular docking with the molecule you as of now have.  

This can yield the molecular target for the new antibiotic.


Related Questions

what is an amino acid

Answers

Amino acids are organic compounds that contain amino and carboxyl functional groups, along with a side chain specific to each amino acid. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen, although other elements are found in the side chains of certain amino acids.
Amino acids are Organic compounds

In dolphins, to have spots on the skin is a recessive trait. One spotted dolphin and one solid gray dolphin have a baby spotted dolphin. Go through the following steps to figure out the genotype of the parent dolphins.

1) what is the genotype of the spotted (recessive) parent?

Answers

Answer:

the spotted parent has the genotype ss

Explanation:

we will use s as the letter when describing the spotted trait.

since spotted is recessive, that parents have to have two little s to have the trait. Since the child also has that, we know that they will have the genotype ss.  the child would have to get a little s from both parents, so the solid parent would have Ss, showing as solid, but still having the gene for spots.

Which gives nourishment to embryo sac??
1) Tapetum
2) Endosperm
3) Thalamus
4)Nucellus​

Answers

Answer:

4 Nucellus

Explanation:

if u think right then follow me

The Nucleus of the embryo gives nourishment. Therefore it is number 4

Name some bubonic plague

Answers

Bubonic plague is one of three types of plague caused by the plague bacterium (Yersinia pestis). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting. Swollen and painful lymph nodes occur in the area closest to where the bacteria entered the skin. Occasionally, the swollen lymph nodes, known as "buboes".

Answer:Today, it's best known as the Black Death or the bubonic plague. Medieval people called it "the blue sickness," La pest ("the Pestilence"), and "the Great Mortality." The name bubonic comes from the medieval Latin word bubo via Italian bilbo--meaning a pustule, growth, or swelling.

Explanation:

What is the term for a number or amount of things?
A. Force
B. Quantity
C. Mass
D. Coordinate

Answers

Answer:

B:Quantity

Explanation:

hope this helps

What happens to the rate at which the reaction happens when the substrate levels increase?

Answers

Answer:

ok

Explanation:

How was osmosis used to stop Clark's seizures?

Answers

Answer:

after Clark was treated with a hypertonic solution? increased Na concentration in matrix of brain caused water from blood to move in to the brain which increased the matrix pressure. Pressure caused the neuron firing rate to increase which increased the likelihood of seizures.

Explanation:

Define the following term:
1. Pinhole camera

2. Screen

Answers

Pinhole camera: a camera with a pinhole aperture and no lens

Screen:a fixed or movable upright partition used to divide a room, give shelter from drafts, heat, or light, or to provide concealment or privacy.

CAN SOMEONE HELP I DONT HAVE MUCH LONGER ON THIS TEST :( !!

Answers

*☆*――*☆*――*☆*――*☆*――*☆*――*☆*――*☆*――*☆**☆*――*☆*――*☆*――*☆

Answer: Prokaryotic

Explanation:

I hope this helped!

<!> Brainliest is appreciated! <!>

- Zack Slocum

*☆*――*☆*――*☆*――*☆*――*☆*――*☆*――*☆*――*☆**☆*――*☆*――*☆*――*☆

Answer:

the correct answer choice is c.

Explanation:

prokaryotic cells lack both a nucleus and membrane-bound organelles.

How do we know that height in humans
is a polygenic trait and not a single-gene
trait?

A. There is no way to know for sure.

B. People have varying heights.

C. Height is too complex to be controlled by a single gene.

Answers

C.........................

Which statement best describes the relationship between an allele and a gene?

A.) An allele is a version of a gene that can be expressed as a phenotype.
B.) An allele is the primary protein made by a gene found in a developing embryo.
C.) An allele is the part of a gene that attaches to messenger RNA molecules.
D.) An allele is a segment of a DNA molecule that controls replication of a gene.

Answers

A.) An allele is a version of a gene that can be expressed as a phenotype.

See above diagram, a represents

Options
water

glucose

oxygen

CO2

Answers

Answer:

water

coz the process begins in stroma

You are breeding alligators to be reintroduced in the wild. One of the female alligators is albino. Would it be possible to get normal colored alligators from this female? Identify the genotypes of each individual and show your work in
the Punnett squares below.

Answers

Answer:

It is possible for normal coloured alligators to be produced. If the albino trait is recessive and normal is dominant, the male would need 1-2 dominant alleles to produce a normal coloured alligator. It is also possible for a normal coloured alligator to be produced if albino is dominant and normal is recessive. In this circumstance, the female must be h e t e r ozygous, but the male can be either h o m ozygous or h e t e r o zygous to produce normal coloured offspring.

First punnet square genotypes:

Female - albino

Male - albino/normal (can be either one)

Second punnet square genotypes:

Female - Normal

Male - albino/normal (can be either one)

the photo is below, pls help

Answers

Answer:

Billiard Ball Model

Explanation:

I used process of elimination.

The plum pudding model looks more like chocolate chip ice cream scoop.

As you can probably tell, that is not a solar system model.

It also is not a nuclear model because those look more like the attached file.

analyze potential impacts of oceans on human populations as the result of climate change in the current century.

Answers

Answer:

The result of climate change is ocean levels increasing because of the increase in temperature. Ice is melting due to climate change and this is causing the ocean levels to rise rapidly. If the ocean levels rise above land, some villages/towns/cities could flood. As a result houses of which people live in and other structures may be destroyed. Water sources may also be contaminated, making the water unsafe for humans to consume.

1.
Which of these statements describes a niche?
- an environmental factor that tends to limit population size

- an increase in the Earth's average atmospheric temperature that causes corresponding changes in
climate, which may result from the greenhouse effect

- the unique living arrangement of an organism defined by its habitat, food sources, time of day it is
most active, and other factors

- none of the above

Answers

C is your correct answer.

- the unique living arrangement of an organism defined by its habitat, food sources, time of day it is most active, and other factors

Answer: the unique living arrangement of an organism defined by its habitat, food sources, time of day it is most active and other factors

Explanation:

yes

Which of the following is a biotic in an ecosystem?

A. Wind

B. Tree leaves

C. Small rocks

D. Light from the sun

Answers

Answer:

tree leavessssssssssssssssssss

Answer:

B. tree leaves

Explanation:

A biotic is something in an ecosystem that are components of a community such as plants and animals. Leaves can be consumed by animals which makes them biotic. Temperature and climate are NOT biotic.

Have a good day.

Yeah Why is global warming a
significant environmental
stressor

Answers

Answer:

it can destroy animal habitat like the penguin of polar bear. plus it causes droughts and severe storms to happen. also I've heard that in the warmest places you can catch diseases more easily.

Why is the scientific name for a gorilla, Gorilla gorilla?

Answers

Answer:

I'm pretty sure it's Gorilla Gorilla Glueilla Rilla

Explanation:

I THINK

half life of plutonium-239 is 24,300 years. if a nuclear bomb released 8kg of this isotope, how many years would pass before the amt is reduced to 1kg

Answers

Answer:

8:2=4kg in 24.300 years

4:2=2 kg in other 24.300 years

2:2=1kg in other 24.300 years

Total time= 72900 years

8.
Which one is a true fish
a) Cuttle fish
b) Star fish
c) Dog fish
d) Silver fish​

Answers

Answer:

Star fish

Explanation:

Answer is (b) Starfish

Discuss in detail to process in which plants produce and use energy

Answers

Explanation:

Plants are autotrophs, which means they produce their own food. They use the process of photosynthesis to transform water, sunlight, and carbon dioxide into oxygen, and simple sugars that the plant uses as fuel.

Which of the following strands are complementary DNA sequences?
Choose 1 answer:

Answers

It's B!!!!!!!!!!!!!!!

Question 8
To what domain does this organism belong?
Domain Eukarya
Domain Bacteria
Domain Animalia
Domain Archeology
Domain Fungi

Answers

Answer:

Domain Eukarya

Explanation:

It sort of looks like a seahorse. And if it happens to be a seahorse, it would belong to the domian eukarya because animals are made of animal cells, and a eukaryotic cell can be either animal cell or plant cell. So it only makes sense for it to belong to domain eukarya (only if it is animal/plant).

Which parts are included in a scientific name? Select all that apply.
1.family 2. species 3. genus 4. phylum

Answers

Answer:

Genus and species name

Explanation:

Scientific names are created to help decrease confusion in the naming process of animals and plants. The first part is the genus which is the origin of the organism and the second part is the species which is what identifies it as plant, animal, and other stuff.

Hope this helps :)

What is a trace fossil?
*USE YOUR OWN ANSWER*​

Answers

Answer:

Its basically traces of an animal and not the actual animal. For example footprints.

Explanation:

PLEASE HELP!!!
In skeletal muscle, calcium ions leave the terminal cistern via the:
a. DHP receptor
b.Nicotinic ACh receptor
c.Ryanodine receptor
d.Calcium ATPase
e. Voltage-gated calcium channel​

Answers

Answer:

c.Ryanodine receptor

Explanation:

Calcium ion release from the SR, occurs in the junctional SR/terminal cisternae through a ryanodine receptor (RyR) and is known as a calcium spark.

what is the time of growth between cell divisions called

Answers

Answer:The time growth between cell divisions is called interphase.

Explanation:


A weather map is shown for the southern United States. According to the map, tornadoes are most closely associated with which
weather event?
A)
blizzards
B)
cyclones
hurricanes
D)
thunderstorms

Answers

D thunderstorms!!! Tornadoes are formed by thunderstorms

A weather map has been shown for the southern United States. According to the map, tornadoes are most closely associated with thunderstorms weather event. Thus, option D is correct.

What is the use of map in weather or garden?

Map is the distribution of flower in a garden. A diagram has been used to label an object so the parts can be recognised easily. A 3-D model has a xerox copy of the object in a three dimensional figure . An information  a word so one can assume infographic . A map helps to represent the layout of the land or distribution of flower in garden.

Geographic information system (GIS) has been analyzed and visualize data for geographic positions on Earth's surface. GIS has computer - based tool that examines spatial relationships, pattern and trends. By connecting geography with data, GIS better understands data using a geographic context.

Therefore, A weather map has been shown for the southern United States. According to the map, tornadoes are most closely associated with thunderstorms weather event. Thus, option D is correct.

Learn more about map on:

https://brainly.com/question/19130581

#SPJ5

What does string theory try to prove?
Provide 1 simple and 1 complicated explanation.

Answers

Answer:String theory hopes to be a literal theory of everything, a single unifying framework that explains all the variety and richness that we see in the cosmosand in our particle colliders, from the way gravity behaves to whatever the heck dark energy is to why electrons have the mass that they do.,

Explanation:

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What is the solution to the equation 38.18 + x = 82.06? A. 44.88 B. 43.88 C. 56.12 D. 44.12 Plz help will mark brainliest which of the following statements are true a. the balance sheet should be prepared before the income statement .b. the income statement should be prepared before the balance sheet c.the balance sheet and the income statenent should be prepared simultaneously. d. the order in which the balance sheet and the income statement are prepared is irrelevent On a social level, Buddhism was differentfrom Hinduism in India in that onDraw3. The weight of a body varies from location to location. Where would the weight of thebody be leastOn the moonAt sea level on earthOn top of Mount EverestIn space4. We meet many different types of force every day. Some of these are shown in the listbelow. However, one of these is NOT a force. Which one is it?ASpeedBPushCPullFriction What is the difference between its and It's? Worth five points !! it doesnt tell me if what answer is right but if i get 75 % or up i will mark the first person who answered with an actual answer brainliest and i don't lie about brainliest !!In the late 1960s, the United Farm Workers used protesting tactics, such as ?, to accomplish their goals.a. boycottsb. riotsc. occupationsd. sit-ins HELP MEEEEE. also if you answer just for the points, your getting reported :))1. Most medical offices use a computerized bookkeeping system. In addition to learning the software for the system, do you think it is important to understand manual bookkeeping components? Why or why not? 2. List and explain 3 advantages and 3 disadvantages of electronic banking. Do you agree with electronic banking? Why or why not? 14y=84there's 2 boxes in the bottom Can someone help me write a journal entry? Today we will revisit Athens & Sparta and discuss some of the ways these two Greek city-states differed. You will thenpick a project to complete to show what you have learned and attach your work here once you are finished. Yourproject will be due after we return from spring break.I have included a How-To video below on how to create a new document and attach it once you are finished.Have fun, guys! I can't wait to see what you create. :) If a triangle has a leg with a length of 6 units and a hypotenuse with a length of 10 units, find the length of the other leg. What does "my heart and tongue are fighting" mean? HELPHELPHELPINEEDTHISHURRY What is the circumference of the outer edge of the path around the pool? NKa12324.816Is the table linear, exponential, Quadratic, or not afunction at all? How does this behavior affect the survival of the eagle population?Someone please help:) Provide a detailed plan, including actual dollar amounts, for Xavier to wisely use the extra $400 per month from his raise. For each part of the plan, briefly describe why you're making this choice. explain why cattle branding is important to the farming and ranching industry. Find the 60th term of the arithmetic sequence -27, -24, -21 write the equation of the line in slope intercept form given a table