Parkinson's disease involves basal ganglia dysfunction due to dopamine deficiency from degeneration of substantia nigra neurons, leading to movement symptoms. Treatment includes medications, surgery, and therapies.
Parkinson's disease affects the basal ganglia in the brain, leading to movement-related symptoms in organs and systems such as tremors, difficulty with motor control, and muscular rigidity.The pathophysiology involves the progressive degeneration of dopamine-producing neurons in the substantia nigra, causing a dopamine deficiency and disrupting the balance of inhibitory and excitatory signals in the basal ganglia.Treatment options for Parkinson's disease include medications like levodopa and dopamine agonists, deep brain stimulation, physical therapy, and surgical procedures like pallidotomy or thalamotomy. Individualized care is necessary for managing symptoms and slowing disease progressionLearn more about basal ganglia here
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