Thyroxine secretion would decrease. With the conversion from T4 to T3 blocked, there would be a reduced availability of active thyroid hormones, resulting in lower levels of thyroxine being produced.
What are the effects of a drug that blocks the conversion of T4 to T3 on TSH secretion, thyroxine secretion, and the size of the thyroid gland?If a drug blocks the conversion of T4 (thyroxine) to T3 (triiodothyronine), it would have the following effects: (a) TSH (thyroid-stimulating hormone) secretion would increase.
Since T3 normally acts as a negative feedback signal to inhibit TSH release from the pituitary gland, blocking its conversion would disrupt this feedback loop, leading to elevated TSH levels.
The size of the thyroid gland would likely remain unchanged. The drug's effect on the conversion of T4 to T3 would primarily impact hormone secretion rather than directly affecting the size of the thyroid gland.
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