Other than tablet hardness, which method is used to measure the tablet strength?

There are 2 main processes to test tablet hardness: compression testing and 3 point bend testing. For compression testing, the analyst generally aligns the tablet in a repeatable way, and the tablet is squeezed between a fixed and a moving jaw. The first machines continually applied force with a spring and screw thread until the tablet started to break. When the tablet fractured, the hardness was read with a sliding scale.

The weight variation test is done to verify the uniformity and the hardness of each batch to know uniformity of drug content in all batches.

To support safety, identity, and quality of the product, statistical quality control test is performed to confirm uniformity of the dosage unit.

The purpose of weight variation test is to make surety of good manufacturing practices (GMP), appropriate size of the tablets and the content uniformity of the formulation.

When the tablets are containing 50 mg or more of drug substance, or  or when the drug substance represents 50% or more (by weight) of the dosage form unit Weight variation test is applied.

Therefore, other than tablet hardness, weight variation method is used to measure the tablet strength.

Learn more about variation test, here:

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What is a dense membrane composed of nerves, blood vessels, and bone-producing cells that
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Gary works for the fire protection services. His primary job responsibility is to make sure that residents and business entities in his assigned territory follow federal, state, as well as city fire rules and regulations. Which of these career roles does Gary perform?

A fire inspector


B fire investigator



C fire prevention specialist



D dispatcher



E fire suppression technician