A researcher wanted to create a loss of function mutation for studying Type I Diabetes in a model animal. What mutation would mimic Type I diabetes

Answers

Answer 1

Answer: A knockout mutation in which the gene is "erased" through a nonsense mutation. In this way, the gene that codes for insuline would be eliminated, and no insuline would be produced.

Explanation:

Type I diabetes is a chronic disease in which no insulin or too little insuline is produced by the pancreas. There are many factors that can trigger Type I diabetes, including genetics and certain viruses. Although Type I diabetes is more likely to appear during childhood or adolescence, it can also begin in adulthood. It is a disease that cannot be cured but can be treated, and treatment focuses on controlling blood sugar levels with insulin injections and a controlled diet.

Insulin is produced by beta cells in the islets of Langerhans of the pancreas. It is a hormone used to allow glucose to enter the cells to produce energy, helping to transport the sugar from the blood to the other tissues of the body. So, through glycolysis and cellular respiration, the necessary energy is obtained in the form of ATP.  

So, we could consider that the gene coding for insulin is not working properly or not working at all. So, a mutation that would mimic Type I diabetes is a knockout mutation in which the gene is "erased" through a nonsense mutation (a point mutation in DNA that results in the appearance of a premature termination codon, so the synthesis of the protein ends earlier, it is not completed). In this way, the gene that codes for insuline would be eliminated, and no insuline would be produced. This type of mutation can be achieved in a laboratory and rhis results in organisms that do not express the gene in a specific tissue or in the whole organism.

Answer 2

When A knockout mutation in which the gene is "erased" through a nonsense mutation. so that In this way, the gene that codes for insulin would be eliminated, and also no insulin would be produced. After that Type I diabetes is a chronic disease in which no insulin or too little insulin is produced by the pancreas. So that many factors can trigger Type I diabetes, which were including genetics and also that are certain viruses. Although Type I diabetes is more likely to appear during childhood or also than adolescence, it can also begin in adulthood. when It is a disease that cannot be cured but can be treated, and also that treatment focuses on controlling blood sugar levels with insulin injections and a controlled diet. According to the Insulin is produced by beta cells in the islets of Langerhans of the pancreas. Then It is a hormone used to allow glucose to enter the cells to produce energy, it helps to transport the sugar from the blood to the other tissues of the body. So, when through glycolysis and also that cellular respiration, the necessary energy is obtained in the form of ATP. So that we could have been considering that the gene coding for insulin is not working properly or not working at all. Then So, a mutation that would mimic Type I diabetes is a knockout mutation in which the gene is "erased" through a nonsense mutation (a point mutation in DNA that results in the appearance of a premature termination codon, so the synthesis of the protein ends earlier, it is not completed). In this way, the gene that codes for insulin would be eliminated, and no insulin would be produced. This type of mutation can be achieved in a laboratory and this results in organisms that do not express the gene in a specific tissue or the whole organism.

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A Researcher Wanted To Create A Loss Of Function Mutation For Studying Type I Diabetes In A Model Animal.

Related Questions

Descibe a structural adaptation for obtaining food of a mammalian predator carnivore.​

Answers

Answer:

Carnivores have biological adaptations that help them hunt. Carnivorous mammals such as wolves have strong jaws and long, sharp teeth that help them grab and rip apart their prey. Plant-eaters, on the other hand, usually have big molars that help them grind up leaves and grasses.

Neptune
?
It is sometimes farther
from the sun than Pluto.
Jupiter
?
It has seasons that last 20
years.
Uranus
?
It has the "Shepherd
Moons."
Saturn
?
It is the largest gas giant.

Answers

Answer:

Neptune is sometimes farther

Uranus has seasons that last 20 years

Saturn has shepherd moons

Jupiter is the largest gas giant

Explanation:

They're probably correct but check

What I Have Learned
Directions: Complete the statements in the paragraph by writing the appropriate
words in the box. Refer to the word box below. Write your answers in your science
activity notebook.

the part where no. 13 is isn't shown so I'll just type it.

Pollution in air, water and soil is the result of these changes, Eventually, causing harm and (13) ______ to living things.

please kindly answer these.

Answers

Answer:

Air pollution can significantly hurt the quality of soil and water resources. When we pollute our air, we are also polluting the precipitation that falls into water bodies and soils.

i need help asap please!!

Answers

Answer:

commensalism

an association between organisms in which one benefits and the other derives nor harm

Need help please and thanks

Answers

Answer:

B

Explanation:

Hope this helpful for you

Yep the answer should be B

Determine the type of inhibition that has occurred in a first order Michaelis-Menten enzyme catalyzed reaction that has yielded the following data. Vi is the velocity in the presence of inhibitor, V is the velocity when run without inhibitor and [S] refers to the substrate concentration. [S] V Vi 3.333 0.283 0.055 1.000 0.260 0.054 0.400 0.222 0.052 0.263 0.197 0.051 0.179 0.171 0.049

Answers

Answer:

competitive inhibition

Explanation:

Given in the first order [tex]\text{Michaelis-Menten enzyme catalyzed reaction}[/tex].

[tex]$V_i$[/tex] = velocity in the presence of the inhibitor

V = velocity when run without the inhibitor.

S = substrate concentration

We need to plot a curve for [tex]$\frac{1}{[V]}$[/tex]  vs  [tex]$\frac{1}{[S]}$[/tex]  and a second plot of  [tex]$\frac{1}{[V_i]}$[/tex]  vs  [tex]$\frac{1}{[S]}$[/tex]

By plotting the curve we see that the slope and the intercept are not the same for the two curves.

And also, the [tex]$V_{max}$[/tex] for the second curve with the inhibitor is lower than the first curve.

Therefore, the inhibition type would be competitive.

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Answers

Answer:

brainliest!?

Explanation:

The distance from the midpoint of a wave to a crest or a trough is the wave’s
a.Amplitude b.Wavelength c.Frequency d.Speed

Answers

Answer:

Amplitude

Explanation:

Amplitude: Distance from the midpoint to a crest (or trough) of the wave. (The “height” of the wave.)

Amplitude is the correct answer for you!

Which geologic structure will most likely take the longest time to form?

1. A fault
2. A sinkhole
3. A river meander
4. A mountain range

Answers

it should be a river mender

¿Cuál es la función principal de la membrana plasmática?

a) Protección
b) Transporte de sustancias
c) Da forma a la célula
d) Síntesis de proteínas

Answers

The answer will be C

Explain how rocks are able to transform into any of the three types of rocks.

Answers

The three processes that change one rock to another are crystallization, metamorphism, and erosion and sedimentation. Any rock can transform into any other rock by passing through one or more of these processes. This creates the rock cycle. Answer:

Explanation:

PLZ HELP ME
electromagnetism is the interaction between _______ and ________
A) Kinetic energy and thermal energy
B) electricity and magnetism
C) North pole and south pole
D) Magnets and light waves

Answers

Answer:

Electromagnetism is a branch of physics involving the study of the electromagnetic force, a type of physical interaction that occurs between electrically charged particles. ... At high energy, the weak force and electromagnetic force are unified as a single electroweak force.

Explanation:

Which layers form Earth’s rigid, mobile tectonic plates?

crust and uppermost mantle

inner and outer core

crust and lower mantle

upper and lower mantle

Answers

crust and uppermost mantle

It takes 100 N to move a box 10 meters in 5 seconds. How much power is
required?
O A 200 W
O B. 5,000 W
C. 1.000 W
O D. 20 W

Answers

Your answer is A 200w

Explain the concept of natural selection using moths as an example.

Answers

Over time moths have changed colours because of natural selection. natural selection is when something is more suited to its surroundings
Moths used to come in two colours black a greyish white the black survived as as the time the factory smokes would be black and would Change the environment colour, the trees turn me would get black from that smoke so the black moths could blend into them while the white ones could be seen and eaten

Role of liver in carbohydrate metabolism.

Answers

Answer:

In the metabolism of carbohydrates, the liver helps to ensure that the level of sugar in your blood (blood glucose) stays constant. If your blood sugar levels increase, for example after a meal, the liver removes sugar from blood supplied by the portal vein and stores it in the form of glycogen.

Explanation:

Are chicken nuggets more like a taco or a hamburger?!?!?! I NEED TO KNOW!!!!!!!!!!!!!

Answers

Answer:

HAMBURGER???

Explanation:

Answer:

hamburger

Explanation:

how does genetic factors influence the growth of trees in a forest?

Answers

Hi there. An answer is below!

Explanation:

The genotypes in a plant determines the amount of time it takes to grow. For example, if a plant has genotypes that are young, they will grow quicker. A plant that has older genotypes will grow slower. These genetic factors are what make trees grow quicker or slower than each other.

Some of the organic material manufactured in the estuarine communities is exported to other ecosystems. What type of ecosystems receive this material

Answers

Answer:

Coastal and open-water ecosystems

Explanation:

Organic material manufactured in estuarine communities is exported to coastal and open water ecosystems. This organic material is very beneficial to these ecosystems as it allows many nutrients to float in the changing tides. These nutrients are a very rich food source for coral reefs and kelp forests. Furthermore, these nutrients arrive in the ecosystem in the form of debris that can serve as breeding grounds for very important organisms in the region and that serve to maintain the food chain.

Which of the following statements about the energy needs of cells is false?

1. The most usable energy for cells comes from the rapid combustion of glucose
2. Many cellular reactions have an associated activation energy
3. The laws of thermodynamics force cells to acquire energy
4. Without a continuous input of energy, cell disorder will increase

Answers

Answer:

A the most usable energy for cells comes from the rapid combustion of glucose

The statement 'the most usable energy for cells comes from the rapid combustion of glucose' is FALSE (Option 1).

Glucose is a simple carbohydrate that provides a rapid energy source to the cells.

In animals, glucose is used to produce glycogen, which is a complex carbohydrate that provides a long-term source of energy.

All metabolic reactions in a cell depend on the presence of activation energy, which generally is provided by ATP, the energy coin of the cell.

In conclusion, the statement 'the most usable energy for cells comes from the rapid combustion of glucose' is FALSE (Option 1).

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Cual hormona de la pituitaría estimula la producción de testosterona?

Answers

Explanation:

Cuando los niveles de testosterona están bajos, la hormona liberadora de gonadotrofina (GnRH) es liberada por el hipotálamo que a su vez estimula la glándula pituitaria para liberar LH. Esta última hormona estimula los testículos para sintetizar la testosterona.

Answer: hormona Folículo-estimulante (FSH) y hormonas luteinizing (LH) - estas hormonas se conocen colectivamente como gonadotropinas, que estimulan el ovario para liberar el estrógeno y progesterona y los testículos para liberar la testosterona

Explanation:

Which of the following best describes the producers in a terrestrial food web?
a- They convert energy from the sun to chemical energy.
b- They are at the top of the energy pyramid.
c- They are unaffected by decomposers.
d- They obtain their energy from consumers.

Answers

Answer:

The correct answer is - a- They convert energy from the sun to chemical energy.

Explanation:

Producers in any food web or ecosystem are the organism that can produce the food and energy on their own. Normally these organisms are green plants that can perform photosynthesis in order to produce chemical energy from light energy that comes from the sun.

Producers not only provide food and energy to themselves but also provide food and energy to each trophic level directly or indirectly. Producers are present at the base of the energy pyramid.

Select the correct anter
Which set of proteins assist in the process of adding amino acids one by one to the growingamine and chain during transfer
Initiation factors
B. Elongation factors
C. Release factors

Answers

Answer:

b

Explanation:

SOMEBODY HELP NO LINKS

Answers

All of the above .

El NIÑO is a climate pattern that describes the unusual warming of the surface waters in the eastern of the tropical Pacific Ocean .

It affects the climate so all the above are impacted by it.

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above has a mass of 30 kg the area of the base is 150 metre square find the pressure exerted by the box on the floor

Answers

I’m also stuck on this question

Which of the following describes a phenomenon occurs when we observe plants that wilt

Answers

Answer:

according to Brainly;"The xylem releases all its water, describes a phenomenon that occurs when we observe plants that wilt"

Explanation:

hope this is helpful

Answer:

The Stomata close, cutting off transpiration and gas exchange.

Explanation:

When the plant wilts, its stomata close in an attempt to maintain homeostasis.

list 10 uses of radiation​

Answers

Answer:

Security

Space Exploration

Measurement

Sterilization/Irradiation

Carbon Dating

Promoting Genetic Mutation

Clean Air

Smoke Detectors

nuclear medication

x-rays

Explanation:

I don’t understand this can someone help me

Answers

i didnt understand it too sorry

Answer: C) Longitudinal wave

Explanation: the wave has the same behavior as a longitudinal wave does

Tại sao tóc có mầu đen

Answers

Answer:

Melanin is responsible for black colour of hair.

Explanation:

Hair is black in colour because it is determined by the amount of a pigment present in hair is called melanin. If eumelanin which is a type of melanin, present in hair, it gives people black or brown hair. If the receptor is not activated or is blocked in the hair, then melanocytes make pheomelanin instead of eumelanin and then the black or brown hair colour did not occurs so we can conclude that melanin is responsible for black colour of hair.

Super saturated solutions are used to make rock candy. Please describe how the crystals are formed, be sure to use the terms Solute and Solvent.

Answers

Answer:

Once the solution cools, it now has more solute than it normally could have, and this is called a supersaturated solution. Once a solution becomes supersaturated, it wants to crystallize the excess solute. The solute will form crystals on any surface. In our case the surface is a string, and we are using a lifesaver candy as our “seed.”

Explanation:

Rock candy is a type of candy made by growing sugar crystals on a string or stick.

Why are Super saturated solutions used?

Super saturated solutions are often used to make rock candy because they contain more solute (sugar) than the solvent (water) can normally dissolve at a given temperature.

The first step in making rock candy is to heat water in a saucepan and add sugar to it. The sugar dissolves and forms a solution as the water heats up. After that, the solution is heated until it is completely saturated.

This occurs because the super saturated solution is unstable, and the excess solute (sugar) in the solution wants to escape and form crystals.

As time passes, more sugar dissolves from the solution and adheres to the crystals on the string or stick, causing them to grow larger.

The process is repeated until the crystals reach the desired size or until all of the excess solute has been removed from the solution.

Thus, preparing a super saturated solution of sugar and water, then dipping a string or stick into the solution and allowing the excess solute to come out of the solution and form crystals on the string or stick, is the process of making rock candy.

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