40 yr old man, skin very sensitive to sunlight, formation of vesicles and blisters due to increase synthesis of compounds in skin subject to excitation of visible light. What biochem pathway defective ?

Answers

Answer 1

Therefore, this is a genetic condition that cannot be cured, and individuals who suffer from it must take appropriate precautions to protect themselves from sunlight to avoid complications.

The biochemical pathway that is likely defective in a 40-year-old man with skin that is sensitive to sunlight, the formation of vesicles and blisters due to an increase in the synthesis of compounds in skin subject to the excitation of visible light is the nucleotide excision repair (NER) pathway. It is important to note that it is a very intricate pathway.

The NER pathway's primary role is to identify and eliminate many types of DNA damage induced by a range of chemical and physical insults, including ultraviolet light (UV) from the sun. It is also capable of repairing specific types of DNA damage induced by a range of chemical and physical stimuli, such as cyclobutane pyrimidine dimers (CPDs), which are commonly caused by UV light.

This pathway's malfunction causes xeroderma pigmentosum (XP), which is a severe genetic disorder. XP is a rare, autosomal recessive disorder characterized by an extreme sensitivity to sunlight. The individual has a significantly increased risk of skin cancer because of a defect in DNA repair. There is no known cure for XP. Treatment involves preventing symptoms and skin damage.

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Related Questions

There are _______ amino acids that are uniquely combined to make up proteins important for human health and wellness

A. 10
B. 20
C. 50
D. 100

Answers

There are 20 amino acids that are uniquely combined to make up proteins important for human health and wellness. These 20 amino acids differ from one another based on their side chains, which are also known as R groups.

Amino acids are the building blocks of proteins. In order for a protein to form, amino acids must be linked together in a specific order and shape. This is known as the protein’s primary structure. The side chains of the amino acids play a crucial role in determining the protein’s overall shape, which in turn influences its function.There are two types of amino acids: essential amino acids and non-essential amino acids. Essential amino acids are those that cannot be produced by the body and must be obtained through the diet.

Non-essential amino acids, on the other hand, can be produced by the body.Both essential and non-essential amino acids are necessary for human health and wellness. They play important roles in a wide range of bodily processes, from muscle growth and repair to the production of hormones and enzymes.

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the percentage of members of a population who have a given trait at the time of a study"" – what is this definition describing?

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The definition that describes the percentage of members of a population who have a given trait at the time of a study is prevalence. This is a statistic term that is used in medicine, epidemiology, public health, and in other related disciplines.

Prevalence is a statistical term that describes the percentage of members of a population who have a given trait at the time of a study. The trait can be any condition, such as a disease or a disorder, or a behavior, such as smoking or physical inactivity. In medical research, prevalence is a measure of how common a particular condition is in a population.The prevalence of a disease or disorder can be calculated in a variety of ways, depending on the study design and the data available.

In cross-sectional studies, prevalence is calculated by dividing the number of individuals with the condition at the time of the study by the total number of individuals in the population. In longitudinal studies, prevalence can be calculated by dividing the number of individuals with the condition at any point during the study by the total number of individuals in the population.The concept of prevalence is important in public health and epidemiology, as it provides an estimate of the burden of a particular condition in a population. Prevalence data can be used to identify populations at higher risk for a particular condition and to guide the development of prevention and intervention strategies.

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Which of the following sexually transmitted bacteria is a significant cause of blindness in humans? 1)Treponema B)Listeria C)Chlamydia D)Neisseria.

Answers

The sexually transmitted bacteria that is a significant cause of blindness in humans is Chlamydia. imperative to practice safe sex, including the use of condoms to prevent sexually transmitted infections (STIs) like Chlamydia.

The correct option is -C Chlamydia.

Chlamydia is a sexually transmitted bacterial infection. The bacteria that cause Chlamydia are the Chlamydia trachomatis. It is common in sexually active individuals, and often does not exhibit any visible symptoms. But, if left untreated, it could lead to several severe and life-threatening complications.

In addition to genital infection, Chlamydia infection can also lead to trachoma (a chronic bacterial infection of the eye). Trachoma is a significant cause of blindness in humans, accounting for 5-10% of all causes of blindness. Therefore, it is imperative to practice safe sex, including the use of condoms to prevent sexually transmitted infections (STIs) like Chlamydia.

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because genetic information is transmitted from one generation to the next which of the following is observed?

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As genetic information is transmitted from one generation to the next, the fact which is observed is that, more than 100 genetic disorders result from genetic mutations. A genetic mutation is a change in the sequence of DNA in a gene, which affects the gene's final product.

Genetic mutations can be inherited or acquired throughout a person's lifetime.The genetic material that determines an individual's characteristics is contained in the DNA of the chromosomes. In every cell of a person's body, except red blood cells, there are 46 chromosomes arranged in 23 pairs. Each pair of chromosomes contains genes that are responsible for various traits or characteristics.There are more than 100 genetic disorders that result from genetic mutations. Some examples include sickle cell anemia, cystic fibrosis, and Huntington's disease.

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Explain what a feedback is. (for climate)
Explain what positive and negative feedbacks are. (for
climate)
Give and explain at least two examples of positive feedbacks in
the Earth’s climate system.

Answers

Feedback is the process by which a certain effect is amplified or counteracted by the inputs that initiated it. In the context of climate, feedback refers to the way in which Earth's climate system responds to changes, whether those changes are initiated by natural or human factors. Positive and negative feedbacks are two types of feedback in climate.

Positive feedback amplifies the initial response of the climate system to external factors, resulting in further changes that reinforce the initial response. This may lead to runaway effects in the climate system. A simple example of positive feedback in the Earth's climate system is the ice-albedo feedback. When snow and ice melt, the albedo (reflectivity) of the surface decreases. This means that less sunlight is reflected back into space and more is absorbed by the Earth, leading to further warming. This, in turn, causes more melting, which further reduces albedo, and so on.

Negative feedback counteracts the initial response of the climate system to external factors, resulting in changes that dampen the initial response. This may lead to a stabilizing effect on the climate system. A simple example of negative feedback in the Earth's climate system is the carbon cycle feedback. When atmospheric CO2 levels increase, more CO2 is absorbed by the oceans and terrestrial ecosystems. This, in turn, reduces the amount of CO2 in the atmosphere, leading to less warming.

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Phospholipids spontaneously form a bilayer in an aqueous solution. Why do the heads of the phospholipids point out and the tails point toward one another?


a) The tails are repelled by the aqueous environment, and the heads will directly interact with the aqueous solution.
b) The heads are repelled by the water inside and outside the cell.
c) The tails are nonpolar and form hydrogen bonds with one another.

Answers

The reason for phospholipids spontaneously forming a bilayer in an aqueous solution with the heads of the phospholipids pointing out and the tails pointing towards one another is option A.

The tails are repelled by the aqueous environment, and the heads will directly interact with the aqueous solution. phospholipid bilayer is the basic structure of the cell membrane. It is made up of two layers of phospholipid molecules, each having a hydrophilic (water-loving) head and a hydrophobic (water-fearing) tail.

The tails of the phospholipids are made up of fatty acids, which are hydrophobic, while the heads are made up of a glycerol molecule and a phosphate group, which are hydrophilic. Because of this, the heads of the phospholipids will interact directly with the aqueous environment (either inside or outside of the cell) while the tails will avoid water and instead associate with one another.Phospholipids spontaneously form a bilayer in an aqueous solution because the hydrophilic heads are attracted to water molecules, whereas the hydrophobic tails are repelled by water and will interact with each other instead.

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